Here are the results that I get with Syndicate Wars:
VDMSound not loaded:
SETSOUND does not detect SB PRO, does not detect SB16. Does detect SB.
With SB selected (IRQ5), the game does not have sound and it crashes.
VDMSound loaded:
SETSOUND does detect SB16, SB PRO and SB.
With SB16 selected, there is a loud stuttering sound when the game is started. Does not crash.
With SBPRO selected, the game plays with sound - on both speakers. When auto-detected, dig.ini has IRQ set to 5. If IRQ=7 is manually selected within SETSOUND, the game also works with sound.
With SB selected, same results as SBPRO.
The game plays without audio if SETSOUND has not been used to detect the digital audio section. It does not crash.